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San Diego Zoo is open every day including holidays. It opens at 9am every day and during the summer months it generally remains open until 9pm and closes at 5pm during the winter. However there are exceptions such as Christmas Day when the zoo is open until 8pm. You can check the exact daily listing at https://zoo.sandiegozoo.org/visit#hours .
Taxi- the zoo is just 5 miles from the International Airport and a taxi takes a little over 10 minutes.
Train- Amtrak and Coaster trains stop at the Santa Fe depot from there it is less than 4 miles to the zoo.
Bus- The number 7 bus operates from the city centre including the train station to the zoo.
MTS- the rapid transit system with service number 215 operating to the zoo.
Car- the zoo is signposted when travelling from all directions. Zoo parking is available on Park Blvd, at Zoo Place.